Case Reports

doi: 10.1111/cup.14307.

Online ahead of print.


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Case Reports

Jose Coelho-Lima et al.

J Cutan Pathol.



Atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS) are unusual cutaneous tumors that typically arise in sun-damaged skin of elderly individuals. Several histopathologic variants have been described, but the clear cell variant is particularly rare with only 18 cases of AFX and 1 case of PDS reported. Here, we present two cases of clear cell AFX and PDS highlighting key histopathologic findings and molecular alterations assessed by next generation sequencing (NGS).


atypical fibroxanthoma; clear cell histopathologic variant; next generation sequencing; pleomorphic dermal sarcoma.