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Prof. Harry Noller | Genetics | Best Researcher Award

Professor of Molecular, Cell and Developmental Biology at University of California at Santa Cruz, United States.

Dr. Harry F. Noller is a prominent figure in molecular biology, with a longstanding research focus on ribosome structure and function. His contributions span over five decades and include pioneering work that has advanced our understanding of protein synthesis and RNA mechanics. Currently serving as the Robert Louis Sinsheimer Professor of Molecular Biology at UC Santa Cruz, he has held key positions, such as Director of the Center for Molecular Biology of RNA, and has been recognized with prestigious awards, including the Breakthrough Prize in Life Sciences (2017). His extensive publication record and numerous high-profile speaking engagements reflect his influential role in the field.

Publication Profile

Education

Harry Noller completed his Ph.D. in Chemistry at the University of Oregon in 1965. His postdoctoral training included research at the Medical Research Council Laboratory of Molecular Biology in Cambridge, England, and at the University of Geneva’s Institute of Molecular Biology. This combination of high-caliber training and early-career experiences fostered his expertise in molecular biology, leading to his appointment at UC Santa Cruz in 1968, where he has contributed greatly to RNA and ribosome research throughout his career

Experience

Dr. Noller’s career has spanned roles as an assistant professor, a professor, and the Robert L. Sinsheimer Professor of Molecular Biology at UC Santa Cruz. In addition to his longstanding role as the Center for Molecular Biology’s director since 1992, he was named the Sherman Fairchild Distinguished Scholar at the California Institute of Technology. His work spans from fundamental biochemistry to innovative structural analyses of ribosomes, blending disciplines to unravel complex biological processes

Awards and Honors

Dr. Noller has earned numerous awards, including the prestigious Breakthrough Prize in Life Sciences, the Canada Gairdner International Award, and the Massry Prize. His work in RNA biology has been globally recognized, with honors like the Paul Ehrlich and Ludwig Darmstaedter Prize and the RNA Society Lifetime Achievement Award. These accolades celebrate his groundbreaking research into ribosome mechanisms, which holds immense value for both molecular biology and antibiotic development

Research Interest

Dr. Noller’s research has profoundly influenced our understanding of ribosomes, especially regarding RNA’s active role in protein synthesis. His work has shown that RNA, not protein, is the core catalyst in peptide bond formation within the ribosome. This revelation has expanded knowledge in molecular biology and medicine, particularly in antibiotic research, where understanding ribosomal RNA helps explain how certain antibiotics inhibit bacterial protein synthesis​

Conclusion

Dr. Harry F. Noller’s career achievements, particularly in ribosomal research, leadership, and impactful publications, make him a prime candidate for the Best Researcher Award. His contributions to molecular biology have shaped the field profoundly, and his ongoing dedication to understanding ribosomal function aligns well with the award’s criteria. His work has not only provided fundamental insights but also paved the way for future innovations in molecular and cellular biology.

Publication Top Notes

“Implication of nucleotides near the 3′ end of 16S rRNA in guarding the translational reading frame”

Authors: Smart, A., Lancaster, L., Donohue, J.P., Niblett, D., Noller, H.F.

Citations: 0

Year: 2024

“The role of GTP hydrolysis by EF-G in ribosomal translocation”

Authors: Rexroad, G., Donohue, J.P., Lancaster, L., Noller, H.F.

Citations: 9

Year: 2022

“The universally conserved nucleotides of the small subunit ribosomal RNAs”

Authors: Noller, H.F., Donohue, J.P., Gutell, R.R.

Citations: 12

Year: 2022

“Mutations in domain IV of elongation factor EF-G confer -1 frameshifting”

Authors: Niblett, D., Nelson, C., Leung, C.S., Lancaster, L., Noller, H.F.

Citations: 9

Year: 2021

“The structural basis for inhibition of ribosomal translocation by viomycin”

Authors: Zhang, L., Wang, Y.-H., Zhang, X., Zhou, J., Noller, H.F.

Citations: 16

Year: 2020

“On demand delivery and analysis of single molecules on a programmable nanopore-optofluidic device”

Authors: Rahman, M., Stott, M.A., Harrington, M., Hawkins, A.R., Schmidt, H.

Citations: 20

Year: 2019

“Co-temporal Force and Fluorescence Measurements Reveal a Ribosomal Gear Shift Mechanism of Translation Regulation by Structured mRNAs”

Authors: Desai, V.P., Frank, F., Lee, A., Tinoco, I., Bustamante, C.

Citations: 40

Year: 2019

“A tandem active site model for the ribosomal helicase”

Authors: Amiri, H., Noller, H.F.

Citations: 11

Year: 2019

“Spontaneous ribosomal translocation of mRNA and tRNAs into a chimeric hybrid state”

Authors: Zhou, J., Lancaster, L., Donohue, J.P., Noller, H.F.

Citations: 36

Year: 2019

“Structural evidence for product stabilization by the ribosomal mRNA helicase”

Authors: Amiri, H., Noller, H.F.

Citations: 16

Year: 2019

 

 

Harry Noller | Genetics | Best Researcher Award

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