Prof. Lan Hong, Department of Physiology and Pathophysiology College of Medicine, Yanbian University, China
Prof. Lan Hong is a distinguished professor and doctoral supervisor at Yanbian University, China, specializing in physiology and pathophysiology. With a Ph.D. in Physiology from Yanbian University, her research focuses on myocardial infarction, cardiac endocrine hormones, and stem cell therapy for heart regeneration. Prof. Hong has held prominent roles at Texas A&M University and led several significant research projects funded by the National Natural Science Foundation of China. She is an active member of various scientific societies, including the Chinese Physiological Society. Her research aims to uncover novel mechanisms for cardiovascular protection and regeneration. 🌟🫀
Publication Profile
Google Scholar
Education 🎓
Prof. Lan Hong completed his educational journey at Yanbian University School of Medicine, Yanji, China. He earned his Ph.D. in Physiology and Pathophysiology (2009-2012), following a Master’s degree in the same field (2006-2009). His foundational studies were rooted in Clinical Medicine, culminating in a Bachelor’s degree (2001-2006). Prof. Hong’s extensive academic background laid the groundwork for his pioneering research in cardiovascular health, particularly in myocardial infarction, cardiac regeneration, and stem cell therapies. His educational achievements reflect his deep commitment to advancing medical science and physiology. 📚💉
Professional Experience 💼
Prof. Lan Hong is currently a Professor at the Yanbian University School of Medicine (2024–Present) in the Department of Physiology and Pathophysiology. Previously, he served as an Associate Professor at the same institution (2019–2023). Prof. Hong has also made significant contributions to regenerative medicine during his time in the Biomedical Institute for Regenerative Research (BIRR) at Texas A&M University – Commerce, Texas, where he worked as a Research Assistant (2019), Research Assistant Professor (2017–2018), and Postdoctoral Research Associate (2017). His earlier academic role included an Instructor position at Yanbian University (2013–2017). 🌍🔬
Research Support 🔬💡
Prof. Lan Hong has led numerous groundbreaking research projects as a Principal Investigator. Currently, he is investigating how LncRNA-CIR can repair infarcted hearts by inducing MSCs into cardiomyocytes through CDK1, supported by the National Natural Science Foundation of China (2024–2027). His prior work includes exploring ANP’s cardioprotective effects against ischemia/reperfusion injury (2018–2021), as well as preclinical studies on induced pluripotent stem cell therapy for myocardial infarction (2021–2024). Prof. Hong has also led projects on Ginseng’s effects on myocardial protection and Schisandrin B‘s impact on ischemic injury, further advancing cardiovascular research. ❤️🧬
Research Focus Areas 🔬❤️
Prof. Lan Hong’s research spans multiple facets of cardiovascular physiology, cell signaling, and pharmacology. His work primarily investigates the secretion of atrial natriuretic peptide (ANP) in response to hypoxic conditions and various pharmacological agents. His studies explore pathways like MAPK, PI3K, and HIF-1α, which regulate cardiac function and response to injury. Additionally, Prof. Hong has contributed significantly to antimicrobial drug development, particularly against methicillin-resistant Staphylococcus aureus (MRSA) and other resistant pathogens. His research also delves into mitochondrial stress, cell signaling pathways, and pharmacological interventions for myocardial protection. 💉🧬⚡
Publication Top Notes
- Synthesis and antibacterial evaluation of rhodanine-based 5-aryloxy pyrazoles against MRSA and QRSA – European Journal of Medicinal Chemistry, 2013 (57 citations) 🦠
- MAPK and PI3K pathways regulate hypoxia-induced atrial natriuretic peptide secretion – Biochemical and Biophysical Research Communications, 2013 (38 citations) 💓
- Atrial natriuretic peptide prevents mitochondrial permeability transition pore opening – European Journal of Pharmacology, 2012 (37 citations) 🔬
- Synthesis and biological evaluation of 5-aryloxypyrazole derivatives as potential antimicrobial agents – Bioorganic & Medicinal Chemistry Letters, 2012 (35 citations) 💊
- Synthesis and positive inotropic activity of quinolin-7-yl derivatives – Bioorganic & Medicinal Chemistry Letters, 2008 (26 citations) 💥
- Adenosine A2 receptor activation ameliorates mitochondrial oxidative stress – Free Radical Biology and Medicine, 2017 (22 citations) ⚡
- Ethanol attenuates sensory responses in cerebellar granule cells – Neuroscience Letters, 2014 (19 citations) 🍷
- Ouabain stimulates atrial natriuretic peptide secretion via endothelin-1/ETB receptor – Life Sciences, 2012 (16 citations) 💧
- Cathepsins in the extracellular space: Focusing on non-lysosomal proteolytic functions – Cellular Signaling, 2023 (13 citations) 🔬
- Endogenous ET-1 promotes ANP secretion in hypoxic beating rat atria – Peptides, 2019 (12 citations) 🌱