. 2022 May;197(4):497-501.

doi: 10.1111/bjh.18145.

Epub 2022 Mar 22.



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Maurice Swinkels et al.

Br J Haematol.

2022 May.


Von Willebrand disease (VWD) is a bleeding disorder caused by quantitative (type 1 or 3) or qualitative (type 2A/2B/2M/2N) defects of circulating von Willebrand factor (VWF). Circulating VWF levels not always fully explain bleeding phenotypes, suggesting a role for alternative factors, like platelets. Here, we investigated platelet factor 4 (PF4) in a large cohort of patients with VWD. PF4 levels were lower in type 2B and current bleeding phenotype was significantly associated with higher PF4 levels, particularly in type 1 VWD. Based on our findings we speculate that platelet degranulation and cargo release may play a role across VWD subtypes.


VWD; VWF; bleeding disorders; platelet activation; platelet factor 4.



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