Gabriel Espinosa Carrasco | Immunotherapy | Best Researcher Award

Dr at Memorial Sloan Kettering Cancer Center,Spain.

Dr. Gabriel Espinosa Carrasco is a distinguished immunologist affiliated with Memorial Sloan Kettering Cancer Center. His research primarily focuses on T cell activation and the mechanisms of self-antigen recognition in immunology. Dr. Espinosa Carrasco’s work advances our understanding of immune responses in various contexts, bridging the gap between basic science and clinical applications.

Profile:

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Education:

1. Ph.D. in Biological Sciences and Immunology (2011-2016)
   University of Montpellier, INSERM Unit 1183 (France)
   Title: CD8+ and CD4+ T cell activation in response to self-antigens: from the lymphoid tissue to the target organ.
2. Master in Advanced Immunology (2010-2011)
   University of Barcelona (UB), Barcelona (Spain)
3. Bachelor’s Degree in Biology (2004-2010)
   Autonomous University of Barcelona (UAB), Barcelona (Spain)

Research Experience:

1. Post-doctoral Scholar (2022-now)
   Cancer Virotherapy and Immunotherapy Group, Bellvitge Institute for Biomedical Research (IDIBELL)
   Department: Molecular Mechanisms and Experimental Therapy in Oncology
   Supervisor: Dr. Ramon Alemany
   🌟 Focus: Investigating novel virotherapy and immunotherapy approaches for cancer treatment.
2. Post-doctoral Research Scholar (2017-2022)
   Memorial Sloan-Kettering Cancer Center, Immunology Program, New York
   Project: Intratumoral immune triads are required for immunotherapy-mediated elimination of solid tumors.
   Supervisor: Dr. Andrea Schietinger
   🔬 Focus: Enhancing the effectiveness of immunotherapies in solid tumors.
3. Ph.D. Student (2011-2016)
   INSERM Unit 1183, Montpellier
   Projects:
   a) Study the cooperation of effector CD8+ and CD4+ T cells in pancreas infiltration and beta cell destruction in real-time.
   b) Role of bacterial product translocation in the breakdown of CD8+ T cell peripheral tolerance under lymphopenic conditions.
   Supervisor: Dr. Javier Hernández
   📚 Focus: Understanding T cell interactions and their role in autoimmune responses.
4. Master Internship (2010-2011)
   Institute of Biotechnology and Biomedicine, Barcelona
   Analysis of peptides directory associated with HLA class I molecules from human thymus and spleen.
   Supervisor: Dr. Iñaki Alvarez
   🔬 Focus: Peptide analysis and immune recognition.
5. Bachelor’s Internship (2008-2009)
   Institute of Biotechnology and Biomedicine, Barcelona
   Composition analysis of the HLA-DR-associated human thymus peptidome.
   Supervisor: Dr. Iñaki Alvarez
   🔬 Focus: Immune system peptide composition.

Research Interests:

Dr. Espinosa Carrasco’s research primarily focuses on T cell activation, self-antigen recognition, and the development of new therapeutic strategies for autoimmune diseases and cancer immunotherapy. His work aims to elucidate the complex interactions within the immune system to enhance treatment efficacy

Awards and Honors:

• 2024: Provisionally selected for the “Best Researcher Award 2024” (ACA awards)
• 2022: Selected Speaker, Recent insights into Immuno-Oncology, Leuven, Belgium
• 2021-2022: Grant recipient, Ludwig Center Basic and Translational Immunology Postdoctoral RFA Memorial Sloan Kettering Cancer Center, New York, USA. $100,000/year
• 2019: Third prize poster presentation award, Tumor Microenvironments: Mechanisms and Therapeutic Implication 6th Annual Symposium, New York, USA
• 2017: Invited seminar speaker, Georgetown University, Department of Microbiology and Immunology
• 2016: Excelente Cum Laude Tesis Doctoral, University of Montpellier, Montpellier, France
• 2015: Best poster presentation award, Institute for Regenerative Medicine and Biotherapy Annual Retreat, Montpellier, France
• 2014: Travel Grant, European Association for the Study of Diabetes conference
• 2012-2015: Research grant from the French Ministry of Research (MRT scholarship), €21,000/year
• 2009-2010: ERASMUS scholarship from the Autonomous University of Barcelona (UAB), University of Nancy

Publications:

• Intratumoral immune triads are required for immunotherapy-mediated elimination of solid tumors. Cancer Cell, 2024. Link.
• TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion. J Exp Med, 2022. Link.
• Fate bifurcation of beta cell-specific CD8 T cells drives type 1 diabetes. Nature, 2022. Link.
• Cytotoxic CD8+ T lymphocytes expressing ALS-causing SOD1 mutant selectively trigger death of spinal motoneurons. Proc Natl Acad Sci USA, 2019. Link.
• Integrin beta 1 optimizes diabetogenic T cell migration and function in the pancreas. Frontiers in Immunology, 2018. Link.
• CD4+ T helper cells play a key role in maintaining diabetogenic CD8+ T cell function in the pancreas. Frontiers in Immunology, 2018. Link.
• Gilz-Activin A as a Novel Signaling Axis Orchestrating Mesenchymal Stem Cell and Th17 Cell interplay. Theranostics, 2018. Link.
• PPARβ/δ directs the therapeutic potential of mesenchymal stem cells in arthritis. Annals of the Rheumatic Diseases, 2016. Link.
• Metabolism Regulates Exposure of Pancreatic Islets to Circulating Molecules In Vivo. Diabetes, 2016. Link.
• Systemic LPS Translocation Activates Cross-Presenting Dendritic Cells but Is Dispensable for the Breakdown of CD8+ T Cell Peripheral Tolerance in Irradiated Mice. PLoS One, 2015. Link.