Xiaocui Wan | Biochemistry | Best Researcher Award

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Dr. Xiaocui Wan | Biochemistry | Best Researcher Award

Dr. Xiaocui Wan, Anhui University, China

Dr. Xiao-Cui Wan is a dedicated PhD student at Anhui University, specializing in peptide and protein engineering. Her research centers on constructing and screening large-scale gene coding cyclic peptide libraries and innovating methods for peptide cyclization. With three first-author publications in top-tier journals, she has already made significant contributions to chemical biology and molecular design. Dr. Wan is passionate about developing novel biochemical tools and has introduced pioneering techniques in peptide synthesis. Her academic diligence and innovative spirit have positioned her as a promising young researcher in molecular biotechnology. 📚🧬🔬

Publication Profile

Scopus

🎓 Education

Xiao-Cui Wan is currently pursuing her PhD in the field of chemical biology at Anhui University, China. Her doctoral research focuses on advanced techniques for constructing peptide macrocycle libraries and modifying protein structures for enhanced biochemical function. Through rigorous training in peptide synthesis, enzymatic cyclization, and molecular display systems, she has developed deep expertise in biomolecular design. She also holds prior academic qualifications in life sciences and biochemistry, forming a strong foundation for her current research. Her educational journey reflects a commitment to innovation, problem-solving, and scientific excellence in the field of molecular biology. 🎓🧪📖

💼 Experience

A PhD candidate at Anhui University, Xiao-Cui Wan has led and contributed to five significant research projects, each focusing on cutting-edge strategies in peptide cyclization and library screening. Her work has resulted in three first-author papers in high-impact journals such as Organic Letters and Chemical Science. She has also collaborated on advanced studies using ligase-based and enzyme-mediated methods for macrocyclic peptide synthesis. While still early in her career, Dr. Wan’s research experiences highlight her growing expertise in synthetic biology and protein chemistry, showcasing her potential as a future leader in peptide therapeutics. 🧫🔍📊

🏅 Awards and Honors

Though still in the early stages of her academic career, Xiao-Cui Wan has achieved significant recognition through her first-author publications in internationally respected journals like Organic Letters and Chemical Science. These accomplishments reflect both the quality and impact of her research. Her innovations in peptide cyclization have earned her distinction among peers and mentors, and her nomination for the “Best Researcher Award” further underlines her contributions to the scientific community. As her career progresses, she is well-positioned to receive further accolades for her pioneering work in molecular biotechnology. 🏆📜🌟

🔬 Research Focus

Dr. Xiao-Cui Wan’s research focuses on the construction and screening of gene-coded cyclic peptide libraries and the structural-functional modification of peptides and proteins. She specializes in enzyme-mediated cyclization techniques, such as using sortase and omniligase for developing macrocyclic ligands. Her work explores novel chemical strategies like thioproline oxidation and phage display systems for therapeutic peptide discovery. These contributions aim to enhance the efficiency and specificity of biologically active molecules. Her research lies at the intersection of synthetic biology, chemical synthesis, and molecular medicine. 🧪🧬💡

Publication Top Notes

  • 📄 Asparaginyl Endopeptidase-Mediated Peptide Cyclization for Phage Display – Organic Letters, 2024
    🔗 DOI: 10.1021/acs.orglett.4c00602
    📅 Published: April 2024

  • 📄 Employing Unnatural Promiscuity of Sortase to Construct Peptide Macrocycle Libraries for Ligand Discovery – Chemical Science, 2024
    🔗 DOI: 10.1039/D4SC01992J
    📅 Published: May 2024

  • 📄 Thioproline-Based Oxidation Strategy for Direct Preparation of N-Terminal Thiazolidine-Containing Peptide Thioesters from Peptide Hydrazides – Organic Letters, 2024
    🔗 DOI: 10.1021/acs.orglett.4c01687
    📅 Published: June 2024

  • 📄 A Ligase-Based Two-Step Approach for the Generation of Bicyclic Peptides Containing a Benzylphenyl Thioether Framework – ChemBioChem, 2025
    🔗 DOI: 10.1002/cbic.202500240
    📅 Published: 2025

  • 📄 Omniligase-1 Mediated Peptide Cyclization for Phage Display – ChemRxiv Preprint, 2025
    🔗 DOI: 10.26434/chemrxiv-2025-58n67-v2
    📅 Published: April 2025

Haidong Bu | Molecular Biology | Best Researcher Award

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Mr. Haidong Bu | Molecular Biology | Best Researcher Award

Mr. Haidong Bu at Mudanjiang Branch of Heilongjiang Academy of Agricultural Sciences, China

Dr. Haidong Bu is an Associate Researcher at the Mudanjiang Branch of the Heilongjiang Academy of Agricultural Sciences with 15 years of experience in horticultural research. He specializes in apple breeding, fruit quality improvement, and plant molecular biology. He has published 75 research papers, including 13 SCI-indexed articles, and contributed to 15 books. Dr. Bu has also led numerous national and provincial research projects and holds multiple patents in fruit tree cultivation. As an expert in horticultural science, he plays a vital role in advancing apple breeding technologies and is actively involved in academic and industry collaborations. 🍏📚

Publication Profile

Orcid

Academic Background🎓

Dr. Haidong Bu holds a Ph.D. in Pomology from Shenyang Agricultural University (2016–2021) and completed postdoctoral research in Horticulture at Heilongjiang Academy of Agricultural Sciences (2022–2024). He earned an M.S. in Pomology (2007–2010) and a B.S. in Horticulture (2003–2007) from Jilin Agricultural University. His academic journey has been dedicated to fruit tree breeding and molecular biology, contributing significantly to apple and pear research. His studies focus on fruit size regulation, stress resistance, and genetic improvement, shaping advancements in the horticultural industry. 🌱🍏

Professional Background🏅

Dr. Haidong Bu has been an Associate Researcher at the Heilongjiang Academy of Agricultural Sciences since 2021, after serving as an Assistant Researcher (2012–2019) and Research Intern (2010–2012). He has also been a Master’s Supervisor at Shenyang Agricultural University since 2018. His expertise in apple breeding and fruit quality improvement has led to significant contributions to cold-region fruit cultivation. With extensive experience in molecular research, he has developed innovative orchard management techniques and disease-resistant fruit varieties, influencing both academia and industry through his leadership and technical expertise. 🌿🧬

Awards and Honors🏆

Dr. Haidong Bu has received multiple prestigious awards, including the Heilongjiang Agricultural Science and Technology Award (Second Prize, 2016) and the Heilongjiang Science and Technology Award (Third Prize, 2017). He was honored as an “Outstanding Individual” by the Heilongjiang Academy of Agricultural Sciences (2021, 2022, 2024) and won First Prize in its Thesis Competition (2021). His research team also earned recognition for excellence (2020–2021, 2024). He was awarded the “Agricultural Science Outstanding Youth” (2022) and the “Young Seedling Award” (2023), acknowledging his contributions to fruit tree research. 🏅🍎

Research Focus🔬

Dr. Haidong Bu’s research focuses on apple and pear breeding, fruit size regulation, stress resistance, and molecular mechanisms influencing fruit development. His work involves gene expression studies related to auxin, ethylene, and histone modifications, contributing to fruit quality improvement. He also explores innovative orchard management techniques, disease-resistant cultivars, and IoT-based monitoring systems for sustainable fruit production. His expertise extends to selenium biofortification, apple disease prevention, and optimizing cold-region fruit cultivation strategies, making a significant impact on horticultural science and agricultural productivity. 🌳🍐

Publication Top Notes

1️⃣ The MdAux/IAA2 Transcription Repressor Regulates Cell and Fruit Size in Apple Fruit 🏵️📖
Year: 2022

2️⃣ Auxin‐activated MdARF5 Induces the Expression of Ethylene Biosynthetic Genes to Initiate Apple Fruit Ripening 🍎🧬
Year: 2020

3️⃣ Histone Acetylation at the Promoter for the Transcription Factor PuWRKY31 Affects Sucrose Accumulation in Pear Fruit 🍐📊
Year: 2020

Conclusion

Haidong Bu is an accomplished researcher in agricultural sciences, specializing in pomology and horticulture, with over 15 years of experience at the Heilongjiang Academy of Agricultural Sciences. He has made significant contributions through 75 research papers (including 13 SCI-indexed), 15 authored books, multiple patents, and the registration of new apple varieties. As an Associate Researcher and Master’s Supervisor, he has led and participated in numerous national and provincial research projects. His outstanding achievements have earned him prestigious awards like the Heilongjiang Science and Technology Award and the Agricultural Science Outstanding Youth Award, making him a strong contender for the Best Researcher Award.

 

 

Genetics and Molecular Biology

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Introduction of Genetics and Molecular Biology

Genetics and Molecular Biology are at the forefront of understanding the intricate machinery that governs life itself. This dynamic field investigates the genetic material and molecular processes underlying inheritance, development, evolution, and the molecular mechanisms of diseases. It is a cornerstone of modern biological research and holds the promise of unlocking the secrets of life’s blueprint.

Genome Sequencing and Analysis:

The study of entire genomes, from humans to microbes, has revolutionized our understanding of genetics. Researchers in this subfield explore the structure and function of genes, regulatory elements, and the role of non-coding DNA.

Genetic Variation and Population Genetics:

Investigating how genetic variations occur within populations and evolve over time is essential for understanding the diversity of life. This subtopic delves into the mechanisms of genetic diversity, adaptation, and speciation.

Epigenetics:

Epigenetics explores changes in gene expression that do not involve alterations to the DNA sequence itself. Researchers study how factors like DNA methylation and histone modification influence gene regulation, development, and disease.

Molecular Mechanisms of Disease:

In this subfield, scientists investigate the molecular basis of genetic disorders and diseases, from cancer to rare genetic conditions. Understanding the underlying mechanisms is crucial for developing targeted therapies.

Synthetic Biology:

Synthetic biology involves the design and construction of artificial biological systems for diverse applications, such as biofuel production or medical treatments. Researchers engineer biological components to create new functions and capabilities.

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