Baijayantimala Swain | Pharmaceutical Medicinal Chemistry Award | Best Researcher Award

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Dr. Baijayantimala Swain | Pharmaceutical Medicinal Chemistry Award | Best Researcher Award

Dr. Baijayantimala Swain, bharat institute of technology- pharmacy, India

Dr. Baijayantimala Swain is an accomplished medicinal chemist with expertise in drug design and discovery, specializing in carbonic anhydrase inhibitors. With a Ph.D. from NIPER Hyderabad, she has synthesized novel compounds targeting various isoforms of carbonic anhydrase, crucial in diseases like cancer and glaucoma. 🧪 Her research has led to the development of potent molecules with therapeutic potential. Dr. Swain’s multidisciplinary skills encompass organic synthesis, analytical techniques, and computational chemistry. She is recognized for her contributions to scientific literature and holds a strong academic background, fostering collaborative research in pharmaceutical sciences. 🎓

 

Publication Profile

Scopus

Academic Qualification 

Dr. Baijayantimala Swain forged her path in pharmaceutical sciences. From her Bachelor’s in Pharmaceutical Sciences at Sri Jaydev College in Odisha, India 🎓, she ventured into deeper realms with a Master’s in Medicinal Chemistry at NIPER, Hyderabad, delving into the intricacies of peptide synthesis for anticancer endeavors. Driven by an insatiable thirst for knowledge, she pursued a Ph.D. in Medicinal Chemistry at the same institute, where she honed her skills in designing novel inhibitors for carbonic anhydrases, under the guidance of esteemed mentors. Each milestone illuminated her academic odyssey, shaping her into a versatile researcher.

 

Research Focus 🧪

Dr. Baijayantimala Swain’s research primarily revolves around the design and synthesis of novel compounds targeting carbonic anhydrases, key enzymes involved in various physiological processes. Her work spans the development of diverse chemical entities, including sulfonamide and non-sulfonamide derivatives, ureidosulfocoumarin derivatives, and indole-based hybrids. These compounds hold promise as potential inhibitors of specific isoforms of carbonic anhydrases, with implications for therapeutic intervention in conditions such as cancer and other diseases. Through innovative approaches and meticulous experimentation, Dr. Swain contributes to the advancement of medicinal chemistry, striving to unlock new avenues for drug discovery and development.

 

Publication Top Notes 
  1. “Design, synthesis, and biological evaluation of 3-benzenesulfonamide-linked 3-hydrazinoisatin derivatives as carbonic anhydrase inhibitors” (2024)
  2. “Design, Synthesis and Biological Assessment of Rhodanine-Linked Benzenesulfonamide Derivatives as Selective and Potent Human Carbonic Anhydrase Inhibitors” (2022) – cited by 1
  3. “Synthesis of a new series of quinoline/pyridine indole-3-sulfonamide hybrids as selective carbonic anhydrase IX inhibitors” (2022) – cited by 7
  4. “Efficient One-pot Synthesis of 3,3-di(indolyl)indolin-2-ones from Isatin and Indole Catalyzed by VOSO4 as Non-Sulfonamide Carbonic Anhydrase Inhibitors” (2022) – cited by 1
  5. “Exploration of 2-phenylquinoline-4-carboxamide linked benzene sulfonamide derivatives as isoform selective inhibitors of transmembrane human carbonic anhydrases” (2022) – cited by 6
  6. “Design and development of novel series of indole-3-sulfonamide ureido derivatives as selective carbonic anhydrase II inhibitors” (2022) – cited by 5
  7. “Design and synthesis of benzenesulfonamide-linked imidazo[2,1-b][1,3,4]thiadiazole derivatives as carbonic anhydrase I and II inhibitors” (2021) – cited by 6

 

 

 

Xintian Shao | Pharmaceutical Science Award | Best Researcher Award

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Dr. Xintian Shao | Pharmaceutical Science Award | Best Researcher Award

Dr. Xintian Shao, Shandong First Medical University & Shandong Academy of Medical Sciences, China

Dr. Xintian Shao earned her PhD in Microbiology and Biochemical Pharmacy from Shandong University, China, under the guidance of Prof. Peixue Ling. She expanded her expertise as a Visiting Scholar in Cancer Biology at the University of Cincinnati, USA, mentored by Prof. Jiajie Diao. Currently serving as an Associate Professor at Shandong First Medical University, her research has yielded 10 impactful publications and secured numerous grants. With two patents to her name, she’s been honored with prestigious awards including the Shandong Medical Science and Technology Award and the Science and Technology Award of Shandong Pharmaceutical Association.

 

Publication Profile 

Scopus

Education and Academic Achievements 📚🏅

Dr. Xintian Shao completed her PhD in Microbiology and Biochemical Pharmacy at the School of Pharmacy, Shandong University, China, under the guidance of Prof. Peixue Ling. She further enriched her expertise as a visiting scholar in Cancer Biology at the University of Cincinnati, USA, mentored by Prof. Jiajie Diao. Her prolific research has resulted in 10 publications, including notable contributions to journals such as Advanced Drug Delivery Reviews and Advanced Science. With multiple patents and prestigious grants to her credit, she has earned recognition including the Shandong Medical Science and Technology Award (2021) and the Science and Technology Award of Shandong Pharmaceutical Association (2022).

Work Experience 💼

Dr. Xintian Shao has served as an Associate Professor at the School of Life Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, China. Her role involves not only teaching and mentorship but also continued research contributions in her field.

Research Focus

Dr. Xintian Shao’s research primarily focuses on subcellular imaging and targeted drug delivery systems. Her work delves into the intricate dynamics of organelle interactions, particularly within mitochondria and lysosomes, employing cutting-edge super-resolution imaging techniques. She explores novel methods for visualizing drug molecules within living organisms, enhancing our understanding of drug distribution and efficacy. With a keen interest in membrane biology and organelle-specific targeting, her contributions shed light on fundamental cellular processes and hold promise for advancements in drug delivery and therapeutics.

Publication Top Notes 

  1. “Single-organelle localization-based super-resolution imaging for subcellular molecules micro-dynamics” by Fang, G. et al., Coordination Chemistry Reviews, 2024.
  2. “Enhanced optical imaging and fluorescent labeling for visualizing drug molecules within living organisms” by Sun, T. et al., Acta Pharmaceutica Sinica B, 2024.
  3. “Mitochondrial nucleoid condensates drive peripheral fission through high membrane curvature” by Chen, Q. et al., Cell Reports, 2023.
    Cited by: 1
  4. “Graphene Oxide Nanosheets Induce Mitochondrial Fragmentation by Cutting through Membrane” by Shao, X. et al., ACS Materials Letters, 2023.
    Cited by: 4
  5. “Subcellular visualization: Organelle-specific targeted drug delivery and discovery” by Shao, X. et al., Advanced Drug Delivery Reviews, 2023.
    Cited by: 7
  6. “Recent advances in fluorescent probes of peroxynitrite: Structural, strategies and biological applications” by Sun, J. et al., Theranostics, 2023.
    Cited by: 8
  7. “Single Image Capture of Bioactive Ion Crosstalk within Inter-Organelle Membrane Contacts at Nanometer Resolution” by Fang, G. et al., Small Methods, 2022.
    Cited by: 8
  8. “Lysosome-Targeted Biosensor for the Super-Resolution Imaging of Lysosome–Mitochondrion Interaction” by Wang, H. et al., Frontiers in Pharmacology, 2022.
    Cited by: 4
  9. “Super-resolution image-based tracking of drug distribution in mitochondria of a label-free naturally derived drug molecules” by Wei, Y. et al., Chemical Engineering Journal, 2022.
    Cited by: 19
  10. “Prefused lysosomes cluster on autophagosomes regulated by VAMP8” by Chen, Q. et al., Cell Death and Disease, 2021.
    Cited by: 24