Prof. Dr. Ching-Chuan Kuo, National Health Research Institutes, Taiwan
π Prof. Dr. Ching-Chuan Kuo earned her Ph.D. in food chemistry and nutraceutical functionality from National Taiwan University. She is an Investigator at the National Health Research Institutes (NHRI) and a Professor at the Biotechnology Center, National Chung Hsing University. π¬ Her research focuses on cancer biology, experimental therapeutics, precision medicine, and translational research. Key contributions include developing four cancer drug candidates that achieved US and Taiwan FDA IND approvals. π Dr. Kuo has authored 108 SCI articles with 5,153 citations, an H-index of 48, and holds two patents. Her work has transformed cancer treatment and precision therapeutics. π§¬
Publication Profile
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Education Background π
Prof. Dr. Ching-Chuan Kuo completed her Ph.D. in Nutritional Biochemistry and Natural Product Chemistry at the Institute of Food Science and Technology, College of Bioresources and Agriculture, National Taiwan University, Taipei, Taiwan, from September 1995 to July 2001. π± Her doctoral research laid the foundation for her distinguished career in cancer biology and experimental therapeutics, blending the fields of food chemistry and biotechnology. Her strong academic background in biochemistry and natural products has driven her groundbreaking work in drug discovery and cancer treatment. π This education has been crucial in her continued success and innovations in translational medicine. π§¬
Professional Experience πΌ
Prof. Dr. Ching-Chuan Kuo has held various prestigious positions throughout her career. Since August 2022, she has been a jointly appointed Professor at the Biotechnology Center, National Chung Hsing University, Taiwan. π± In January 2022, she became an Investigator at the Institute of Biotechnology and Pharmaceutical Research, NHRI, after serving as an Associate Investigator from 2013 to 2021. π¬ Dr. Kuoβs journey began in 2001 as a Postdoctoral Fellow at the Division of Cancer Research, NHRI, followed by roles as a Research Associate and Assistant Investigator at the National Institute of Cancer Research. Her extensive career reflects her expertise and dedication to advancing cancer research. π§¬
Research Interests π¬
Prof. Dr. Ching-Chuan Kuoβs research focuses on several key areas within cancer biology. Her work involves the identification and validation of novel oncotargets, the development of clinically relevant tumor models, and the discovery of new anticancer drugs. π‘ She also explores cancer pharmacology and experimental therapeutics, aiming to improve cancer treatment. Her research extends to understanding chemo- and radio-resistance mechanisms and discovering strategies to overcome them. 𧬠Additionally, Prof. Kuo is deeply invested in precision medicine and translational research, seeking to bridge the gap between laboratory findings and clinical applications to enhance cancer therapies. π±
Publication Top Notes
- Cytotoxic triterpenes from the aerial roots of Ficus microcarpa – 259 citations, 2005 ππ
- BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells – 259 citations, 2004 π§ͺπ₯
- Effects of drying and extrusion on colour, chemical composition, antioxidant activities and mitogenic response of sweet potatoes – 196 citations, 2009 π π¬
- 4-Ketopinoresinol, a novel naturally occurring ARE activator – 142 citations, 2012 π±πͺ
- Salvinal, a novel microtubule inhibitor isolated from Salvia miltiorrhizae Bunge – 137 citations, 2004 πΏπ¬
- 2,2β-Diphenyl-1-picrylhydrazyl Radical-Scavenging Active Components from Adlay – 137 citations, 2002 πΎπ§ͺ
- Surface Ξ±-enolase promotes extracellular matrix degradation and tumor metastasis – 136 citations, 2013 π§¬ποΈ
- Antagonism of free-radical-induced damage of adlay seed – 111 citations, 2001 π±π¬
- Scaffold-hopping strategy: synthesis and biological evaluation of 5, 6-fused bicyclic heteroaromatics – 107 citations, 2011 π§¬π¬
- Synthesis and evaluation of 3-aroylindoles as anticancer agents – 107 citations, 2009 ππ¬
- 7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents – 106 citations, 2006 π§ͺπ‘
- Four new 6-nor-5 (6β 7) abeo-abietane type diterpenes from the bark of Taiwania cryptomerioides – 103 citations, 2005 π²π¬