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Mr. Tairan Yuwen | Chemistry | Best Researcher Award

Mr. Tairan Yuwen, Peking University, China

🔬 Tairan Yuwen is an analytical chemist and biochemist specializing in protein systems with structural disorder. With a Ph.D. from Purdue University and a B.Sc. from Peking University, their research spans from understanding molecular interactions to developing new NMR methodologies. Currently an Assistant Professor at Peking University, they’ve held postdoctoral positions at the University of Toronto and Purdue University. Yuwen’s contributions include innovative NMR techniques showcased in conferences worldwide. Recognized with honors like the CIHR Fellowship, they continue to advance understanding in biomolecular dynamics and drug discovery. 🌱

Publication profile:

Orcid

Education:

🔬 Tairan Yuwen’s academic journey in the sciences began with a Bachelor of Science degree in Biological Sciences from Peking University, China, where they delved into the intricacies of molecular interactions under the guidance of Professor Luhua Lai. Their undergraduate thesis focused on unraveling the mechanism behind the interaction between Mj HSP 16.5 and amyloid fibrils, contributing to the understanding of protein dynamics.Building on this foundation, Yuwen pursued a Ph.D. in Chemistry at Purdue University in the United States, specializing in Analytical Chemistry and Biochemistry under the mentorship of Professor Nikolai Skrynnikov. Their doctoral research culminated in the development of novel experimental and theoretical tools tailored for studying protein systems characterized by structural disorder. This work represented a significant advancement in the field, shedding light on the complexities of biomolecular structures.Throughout their academic journey, Yuwen’s dedication to unraveling the mysteries of molecular biology has been underscored by a passion for discovery and innovation. Their contributions to both theoretical understanding and experimental techniques exemplify their commitment to pushing the boundaries of scientific knowledge. 🧪

Work Experience:

🔬 Tairan Yuwen’s professional journey spans prestigious academic institutions and cutting-edge research projects. They began as a Postdoctoral Research Fellow at Purdue University, where they worked under the guidance of Prof. Nikolai Skrynnikov, focusing on developing advanced NMR methodologies for probing protein structure and dynamics. Subsequently, at the University of Toronto under Prof. Lewis E. Kay, they continued their exploration of NMR techniques, this time concentrating on large biomolecular systems. Currently, Yuwen serves as an Assistant Professor at Peking University’s School of Pharmaceutical Sciences, where they continue to contribute to the advancement of scientific knowledge and mentor the next generation of researchers. 🌱

Teaching:

🎓 From 2010 to 2014, Tairan Yuwen enriched their academic experience at Purdue University, serving as a Teaching Assistant in the Department of Chemistry. They played a pivotal role within the Purdue Interdepartmental NMR Facility (PINMRF), where they assisted students in mastering the intricacies of nuclear magnetic resonance (NMR) techniques. As a mentor, Yuwen not only facilitated practical learning but also fostered a deeper understanding of analytical chemistry concepts. Their dedication to education, coupled with expertise in NMR methodologies, provided students with invaluable insights and skills essential for their scientific pursuits. Yuwen’s commitment to teaching shines brightly amidst their academic endeavors. 📚

 

Honors and Awards:

🏆 Tairan Yuwen’s exceptional contributions to scientific research were recognized with the prestigious Canadian Institutes of Health Research (CIHR) Fellowship from 2017 to 2020. This esteemed award provided funding for their project focusing on the solution state NMR study of Dot1–nucleosome interactions. Through this fellowship, Yuwen was able to delve deeper into understanding the complex dynamics of molecular interactions within chromatin, shedding light on crucial aspects of gene regulation and epigenetics. Their dedication to advancing knowledge in this field was underscored by this esteemed honor, showcasing Yuwen’s commitment to excellence in scientific inquiry. 🧬

Employment:

🔬 Tairan Yuwen’s professional journey reflects a commitment to academic excellence and scientific inquiry. Starting as a Teaching Assistant at Purdue University’s Interdepartmental NMR Facility (PINMRF), they honed their skills in chemistry education from 2010 to 2014. Subsequently, they embarked on postdoctoral research positions at Purdue University and later at the University of Toronto, delving into biochemistry and advancing NMR methodologies. Presently, Yuwen serves as an Assistant Professor at Peking University’s School of Pharmaceutical Sciences, where they continue to inspire students and contribute to cutting-edge research in pharmaceutical sciences. Their diverse experiences underscore their passion for education and research in the scientific community. 🎓

Research Focus :

🔬 Tairan Yuwen’s research focus lies at the intersection of nuclear magnetic resonance (NMR) spectroscopy and protein dynamics. Their work spans various aspects of NMR methodology development and its application to elucidate molecular interactions and conformational dynamics in biological systems. They have made significant contributions to optimizing relaxation dispersion experiments, exploring chemical exchange processes, and probing conformational dynamics in proteins. Yuwen’s expertise in NMR techniques has paved the way for a deeper understanding of biomolecular structures and interactions, ultimately advancing research in fields such as structural biology and drug discovery. Their dedication to unraveling the mysteries of molecular dynamics is evident in their prolific contributions to scientific literature. 🧪

Publication Top Notes:

Optimization of TROSY- and anti-TROSY-based 15N CPMG relaxation dispersion experiments through phase cycling

Measurement of 1Hα transverse relaxation rates in proteins: application to solvent PREs

Chemical shift prediction of RNA imino groups: application toward characterizing RNA excited states

Understanding and solving abnormal peak splitting in 3D HCCH-TOCSY and HCC(CO)NH-TOCSY

Revisiting 1HN CPMG relaxation dispersion experiments: a simple modification can eliminate large artifacts

A Methyl‐TROSY‐Based 1H Relaxation Dispersion Experiment for Studies of Conformational Exchange in High Molecular Weight Proteins

Measuring Diffusion Constants of Invisible Protein Conformers by Triple‐Quantum 1H CPMG Relaxation Dispersion

Measuring Solvent Hydrogen Exchange Rates by Multifrequency Excitation 15N CEST: Application to Protein Phase Separation

A methyl 1H double quantum CPMG experiment to study protein conformational exchange

Exploring methods to expedite the recording of CEST datasets using selective pulse excitation

Tairan Yuwen | Chemistry | Best Researcher Award

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